Program Sweprot 2023


Download program with abstracts to the oral presentations (PDF)

Friday June 16th

16:30 – 18:00 Conference desk open

18:00 – 19:30 Dinner

19:45 – 21:00 Session Ia: Opening and Awards

Chair: Dr. Knecht & Dr. Burmann

19:45 – 20:15 Welcome, presentation of Keynote Lecturers and the The Svedberg awardee

20:15 – 21:00 The Svedberg Award Lecture: Simon Elsässer (Karolinska Institutet)

21:00 – 22:00 PI meeting

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Saturday June 17th

07:00 – 08:45 Breakfast

09:00 – 12:00 Session II: Beyond classical structural biology

Chair: Dr. Neutze

09:00 – 09:45 Keynote 1: Serena DeBeer (MPI Mühlheim, Germany)

Spectroscopic and computational studies of biological nitrogen reduction

09:45 – 10:05 Katja Bekcic (Karolinska Institutet)

Optimizing large-scale production of circular RNA for in-cell NMR of nucleic acids

10:05 – 10:25 Nicolas Pearce (Linköping University)

Refactoring the B-factor: intuitively extracting structural dynamics from
macromolecular disorder

10:25 – 10:50 Coffee

10:50 – 11:35 Keynote 2: Alan Brown (Harvard Medical School, USA)

10:50 – 11:35 Keynote 2: Alan Brown (Harvard Medical School, USA)

Using cryo-EM to build atomic models of ciliary axonemes

11:35 – 11:55 Vajradhar Acharya (University of Gothenburg)

3D TEM Studies of Mammalian Sperm Extra-Axonemal Structures

11:55 – 12:15 Juliane John (Stockholm University)

XFEL investigation of redox-dependant flavin strain in the ribonucleotide reductase
R2b-NrdI complex

12:20 – 13:40 Lunch

Session III: Membrane proteins in health and disease I

Chair: Dr. Esbjörner

13:40 – 14:25 Keynote 3: Layara Akemi Abiko (Biozentrum Basel, Switzerland)

Influencing the β1-adrenergic receptor conformational equilibrium by targeting its
empty cavities

14:25 – 14:45 Yue Chen (KTH Stockholm)

Mechanism of ligand-dependent D2 dopamine receptor activation revealed by freeenergy landscapes

14:45 – 15:05 Jessica Glas (University of Gothenburg)

High-resolution structure of a fish aquaporin reveals a novel extracellular fold

15:05 – 15:25 Lightning talk

15:25 – 16:00 Coffee

Session IV: Membrane proteins in health and disease II

Chair: Dr. Hedfalk

16:00 – 16:45 Keynote 4: Patrick Sexton (Monash University, Australia)

Advancing GPCR drug discovery using cryo-EM

16:45 – 17:05 Nour Aldin Kahllous (Uppsala University)

Design of drug efficacy guided by free energy simulations of G protein-coupled
receptors

17:05 – 17:25 Alexandra Berg (Umeå University)

Nematocida displodere mechanosensitive ion channel of small conductance 2
assembles into a unique six-channel super-structure in vitro

17:25 – 17:45 Johannes Thoma (University of Gothenburg)

Exploiting OMVs for the in-situ characterization of bacterial envelope proteins

18:00 – 19:30 Dinner

20:00 – 21:30 Poster Session II

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Sunday June 18th

07:00 – 08:45 Breakfast

Session Ib: Awards

Chair: Dr. Morud Lekholm

09:00 – 09:15 Presentation of The Theorell Awardee.

09:15 – 10:00 The Theorell Award Lecture: Marta Carrroni (SciLifeLab Stockholm)

10:00 – 10:30 Coffee

Session V: Integrated structural biology

Chair: Dr. Burmann

10:30 – 11:15 Keynote 5: Sebastian Hiller (Biozentrum Basel, Switzerland)

Integrative structural biology to resolve molecular machines and membrane
megaprores

11:15 – 11:35 Annika Breidenstein (Umeå University)

Structural and functional characterization of the relaxase TraI – Implications for
Gram-negative Type 4 secretion systems

11:35 – 11:55 Vamsi Krishna Moparthi (Linköping University)

Regulation of MYC-MAX DNA binding in cancer

11:55 – 12:15 Oksana Koshla (Uppsala University)

The iron sensing transcriptional factor IdeR and its function in the metabolism of
Saccharopolyspora erythraea

12:20 – 13:40 Lunch

Session VI: Success stories using research infrastructures in Sweden

Chair: Dr. Göran Karlsson

13:40 – 14:00 Bärbel Lorenz (Lumicks)

Molecular tractor beams? Unravelling biological mechanisms by looking at single
molecules in real-time

14:00 – 14:20 Simon Ekström (Lund University)

Cross-linking and Hydrogen-Deuterium Exchange Mass Spectrometry as a National
Infrastructure Service

14:20 – 14:40 Huanbing Wang (Stockholm University/China)

The structural biology in protein folding and aggregation.

14:40 – 15:00 Atsarina Larasati Anindiya (University of Gothenburg)

Prediction of peptide binding to survivin based on experimental microarray
fluorescence intensities.

15:20 – 15:40 Tristan Kenney (Linköping University/University of Toronto)

The dynamic interactions between Myc and RNA Polymerase II component TFIIF
component

15:40 – 16:10 Coffee

16:20 – 18:00 Annual football match

18:00 – 19:30 Dinner

20:00 – 21:30 Poster Session II

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Monday 19th June

07:00 – 08:45 Breakfast

Session VII: Drug discovery

Chair: Dr. Käck

09:00 – 09:45 Keynote 6: Alessio Ciulli (University of Dundee, UK)

How PROTAC degraders work: Molecular recognition and design principles

09:45 – 10:05 Wolfgang Knecht (Lund University)
Structural basis for small molecule binding to SARS-COV-2 nonstructural protein 10

10:10 – 10:30 Coffee

10:30 – 10:50 Andreas Luttens (Uppsala University)

Virtual Fragment Screening for DNA Repair Inhibitors in Vast Chemical Space

10:50 – 11:10 Adrian Gonzales Lopez (Uppsala University)

Cryo-EM structures of Staphylococcus aureus 70S ribosomes in complex with
elongation factor G and fusidic acid

11:10 – 11:30 Sayyed Jalil Mahdizadeh (University of Gothenburg)

I-TripleD, an AI tool for de novo drug discovery

11:35 – 11:50 Closing of meeting and award of prizes for best presentation and poster

12:00 – 13:00 Lunch + Departure