Link to abstracts for posters and oral presentations.
Sweprot 2024 Participant list (pdf)
PROGRAM
Friday June 14
16:30 – 18:00 Check-in
18:00 – 19:30 Dinner
Session I: Opening and The Svedberg Award Lecture
Chairs: Anna Sundborger-Lunna, Maria Selmer, Uppsala University
Wolfgang Knecht, Umeå University
19:45 – 20:00 Welcome and Presentation of Keynote Speakers
20:00 – 20.15 Presentation of the The Svedberg Awardee
20:15 – 21:00 The Svedberg Award Lecture – Björn Reinius, Karolinska Institutet
Multiple routes to achieve sex-chromosome dosage compensation in our cells, Abstract Bjorn_Reinius_2024 (pdf)
21:00 – 22:00 PI meeting
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Saturday June 15
07:00 – 08:45 Breakfast
Session II: Protein Folding and Misfolding
Chair: Stefan Knight, Uppsala University
09:00 – 09:45 KEYNOTE – Amnon Horovitz, Weizmann Institute, Israel
Allostery and function of the chaperonin GroEL nano-machine, Abstract Amnon Horovitz (pdf)
09:45 – 10:05 Hannah Osterholz, Uppsala University
Native MS captures LLPS-specific binding of small molecules to human tau
10:05 – 10:25 João Carlos Marcos, University of Minho
Experimental and computational elucidation of the inhibition of myoglobin aggregation by polyethylene glycol
10:25 – 10:45 Coffee
Session III: Supramolecular Assemblies
Chair: Maria Selmer
10:45 – 11:30 KEYNOTE – Albert Weixlbaumer, IGBMC, France
RNA Polymerase Cooperation with the Ribosome during Translation Initiation, Abstract Albert Weixlbaumer (pdf)
11:30 – 11:50 Inna Rozman Grinberg, Stockholm University
ATP-cone: evolutionary mobile, structurally conserved domain with different regulatory functions
11:50 – 12:10 Bozidar Duic, University of Gothenburg
Deciphering the role of HtrA1 in inflammation and neurodegenerative diseases
12:10 – 13:30 Lunch
Session IV: Molecular Dynamics
Chair: Sebastian Westenhoff, Uppsala University
13:30 – 14:15 KEYNOTE – Angela Gronenborn, University of Pittsburgh, USA
The Lure of Fluorine – from Drugs to Cells
14:15 – 14:35 Leonardo Monrroy, Uppsala University
Microsecond time-resolved X-ray scattering by utilizing MHz repetition rate at second-generation XFEL
14:35 – 14:55 Wei-Sheng Sun, Umeå University
Breaking Barriers: pCF10 Type 4 Secretion System relies on a self-regulating muramidase to modulate the cell wall
14:55 – 15:15 SPECIAL SELECTION: Mattias Fink, Karolinska Institutet
The heat shock protein LarA activates the Lon protease in response to proteotoxic stress
15:15 – 16:00 Coffee
Session V: Structural Biology Beyond Proteins
Chair: Marco Marcia, Uppsala University
16:00 – 16:45 EMBO Young Investigator Lecture – Stephanie Jonas, ETH, Zurich
Assembly mechanism of Integrator’s RNA cleavage module
16:45 – 17:05 Shekhar Jadhav, EMBL/Uppsala University
Structural insights into the assembly mechanism of a large multidomain ribozyme
17:05 – 17:25 Maximilian Vieler, Uppsala University
Large-scale profiling E3-ligases reveals substrate binding specificity determinants
17:25 – 17:45 Jeena Manayath Thekkeyil, Max Planck Institute for Polymer Research
Chaperons-inspired peptide nanofibers interrupt Cu (I) homeostasis in cancer cells
17:45 – 18:00 sponsored content (MiTeGen)
18:00 – 19:30 Dinner
20:00 – 21:30 Poster Session I
21:30 – 00:00 Karaoke disco
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Sunday June 16
07:00 – 08:45 Breakfast
Session VI: Theorell Award Lecture
Chair: Ronnie Berntsson, Umeå University & SFBBM
09:00 – 09:15 Presentation of The Theorell Awardee
09:15 – 10:00 Theorell Award Lecture – Gustav Berggren, Uppsala University
Title: Hydrogenases and microbial H2 gas metabolism
10:00 – 10:30 Coffee
Session VII: Membranes
Chair: Anna Sundborger-Lunna
10:30 – 11:15 KEYNOTE – Alethea Tabor, UCL London, UK
Synthesis, Structure and Biophysics of Membrane-Active Antimicrobial Peptides
11:15 – 11:35 Arni Thorlacius, Uppsala University
BAR protein endophilin-B1 displays multiple assembly forms on artificial lipid discs
11:35 – 11:55 Mia Abramsson, Karolinska Institutet
Engineering cardiolipin binding to an artificial membrane protein
12:00 – 13:30 Lunch
Session VIII: From Atom to Cell
Chair: Sebastian Deindl, Uppsala University
13:30 – 14:15 KEYNOTE – Nico Thomä, FMI & EPFL, Switzerland
Nucleosomes gate cofactor access to the transcription factor p53
14:15 – 14:35 Ved Mehta, Stockholm University
Structure and electromechanical coupling of the sperm specific voltage gated Sodium/Proton exchanger SLC9C1
14:35 – 14:55 Felipe Otsuka, Lund University
Engineering stereospecificity in glycoside hydrolases through mutagenesis
14:55 – 15:25 Coffee
15:25 – 18:00 Free time (Annual football match starts at 16.00)
18:00 – 19:30 Dinner
19:30 – 20:00 Annual Proceedings SFBBM Swedish Chemical Society
20:00 – 21:30 Poster Session II
21:30 – 00:00 Pub Quiz
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Monday 17th June
07:00 – 09:00 Breakfast
Session IX: LINXS Drug Discovery
Chair: Raminta Venskutonytė, Lund University/LINXS
09:15 – 10:00 KEYNOTE – Flavio Ballante, Chemical Biology Consortium Sweden
Structure-guided exploration of commercial chemical space: the Chemical Space Navigator
10:00 – 10:20 Andreas Dunge, University of Gothenburg/AstraZeneca
Exploring serial crystallography for drug discovery
10:20 – 10:40 Coffee
10:40 – 11:00 Marco Marcia, Uppsala University
Targeting the conserved active site of splicing machines with specific and selective small molecule modulators
11:00 – 11:20 Si Min Zhang, Karolinska Institutet
Tailor antimetabolite therapy by targeting host nucleos(t)ide kinase and phosphohydrolase
11:20 – 11:40 SPECIAL SELECTION: Viktoria Bågeholm, University of Copenhagen
Inhibition of a muscle chloride channel – structural and functional studies of ClC-1
11:40 – 12:00 Closing of meeting & Awards for best presentation and poster
12:00 – 13:00 Lunch + Departure