Welcome to the 28th Swedish Conference on Macromolecular Structure & Function (SWEPROT 2025)!
Sweprot is the annual Symposium of SFBBM (Swedish Society for Biochemistry, Biophysics and Molecular Biology) in collaboration with SBNet (Swedish Structural Biology Network), in 2025 arranged by Stockholm University and Karolinska Institutet.
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Program Sweprot 2025
Friday June 13th
16:30 – 18:00 Conference desk open
18:00 – 19:30 Dinner
19:45 – 20:45 Session Ia: Opening and Awards
Chair: Prof. Pål Stenmark
19:45 – 20:00 Welcome, presentation of the Svedberg awardees
20:00 – 20:45 The 2025 Svedberg Award Lecture by Dr. Michael Landreh.
Weighing in: What native mass spectrometry can tell us about elusive protein interactions
20:45 – 21:15 PI meeting
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Saturday June 14th
07:00 – 08:45 Breakfast
09:00 – 11:40 Session II: Multiscale structural biology
Chair: Dr. Marta Carroni
09:00 – 09:45 Keynote 1: Prof. Ulrich Hartl, Max Planck Institute of Biochemistry
Recent aspects of molecular chaperone functions in protein folding
09:50 – 10:10 Lukas Grunewald, Uppsala University
Ultrafast Water Rearrangements in Phytochromes: Unveiling a Remote Proton-Coupled Photoactivation Mechanism
10:10 – 10:30 Johanna Hultman, Linköping University
The N-Myc MB0-MBI region forms a specific, functional and fuzzy complex with the N-lobe of Aurora kinase A
10:30 – 11:00 Coffee
11:00 – 11:20 Candice Gautier, Uppsala University
Linking Structure and Genetics in Usher Syndrome type 2: Multiscale Analysis of the Ankle-Link Complex
11:20 – 11:40 Johannes Panagiotidis, University of Gothenburg
Molecular mechanisms for osmotic regulation in fish
12:00 – 13:30 Lunch
13:30 – 15:20 Session III: Structural enzymology
Chair: Prof. Martin Högbom
13:30 – 14:15 Keynote 2: Prof. Chris Greening, Monash University
Enzymatic energy extraction from atmospheric trace gases
14:20 – 14:40 Moritz Senger, Uppsala University
From Catalysis to Sensing: How Protein Scaffolds Fine-Tune [FeFe]-Hydrogenase function
14:40 – 15:00 Davide Zabeo, University of Gothenburg
Functional and structural characterization of the polymodal ligand-gated ion channel LGC-39
15:00 – 15:20 Gerhard Hofer, Stockholm University
Continuous Serial Electron Diffraction (SerialED) for High-Quality Protein Structures
15:20 – 16:00 Coffee
16:00 – 17:50 Session IV: AI methods in structural biology/structural bioinformatics
Chair: Prof. Arne Elofsson
16:00 – 16:45 Keynote 3: Prof. Martin Steinegger, Seoul National University
Exploring the Protein Universe via Highly Accurate Structural Predictions
16:50 – 17:10 Maria Levkovets, Linköping University
Enhancing Protein Complex Modeling via Automated Structural Homolog Search
17:10 – 17:30 Bernadette Mayer, Gothenburg University
Elucidating KcsA structural dynamics using time-resolved X-ray solution scattering and molecular dynamics simulations
17:30 – 17:50 Yogesh Kalakoti, Linköping University
Improving generative methods to capture conformational diversity in protein ensembles
18:00 – 19:30 Dinner
20:00 – 21:30 Poster Session I
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Sunday June 15th
07:00 – 08:45 Breakfast
09:00 – 10:00 Session Ib: Awards
Chair: Prof. Pål Stenmark
09:00 – 09:15 Presentation of the 2024 Svedberg awardee
09:15 – 10:00 The 2024 Svedberg Award Lecture by Dr. Björn Reinius
Chromosomes and Crises: From X-Chromosome Regulation to Pandemic Diagnostics
10:00 – 10:30 Coffee
10.30 – 12.20 Session V: Membranes
Chair: Prof. David Drew
10:30 – 11:15 Keynote 4: Prof. Simon Newstead, University of Oxford
Identification of SLC45A4 as a pain gene encoding a neuronal polyamine transporter.
11:20 – 11:40 Shu-Chieh Chang, Uppsala University
Bax assemblies visualized in dying cells using super-resolution microscopy
11:40 – 12:00 Hannah Fremlen, University of Gothenburg
Elucidating the functional details of Protein Quality Control of Integral Membrane Proteins by the Bacterial Metalloprotease FtsH
12:00 – 12:20 Viktoria Bågenholm, Lund University
Cryo-EM structure of the human monocarboxylate transporter 10
12:20 – 13:30 Lunch
13:30 – 16:00 Session VI: Nucleotide Metabolism
Chair: Prof. Luca Jovine
13:30 – 14:15 Keynote 5: Prof. Britt-Marie Sjöberg, Stockholm University
The ATP-cone domain controls both expression and enzyme activity of ribonucleotide reductase
14:20 – 14:40 Christopher Dirks, Karolinska Institutet
Antiviral nucleotide analogues trap chemoresistance factor SAMHD1 in an inactive tetrameric state
14:40 – 15:00 Julian Ludäscher, Stockholm University
Structural studies of DNA glycosylases in DNA repair
15:00 – 15:20 Dev Thacker, Lund University
Aggregation of amyloid β 42 in Alzheimer’s patient cerebrospinal fluid
15:20 – 16:00 Sponsored content
16:00 – 16:30 Coffee
16.30 – 18:00 Networking hour
18:00 – 19:30 Dinner
20:00 – 21:30 Poster Session II
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Monday 16th June
07:00 – 08:45 Breakfast
09:00 – 11:50 Session VII: Molecular motions
Chair: Prof. Astrid Gräslund
09:00 – 09:45 Keynote 6: Prof. Dorothee Kern, The Scripps Research Institute
The Protein Dance – from Experiments to AI Predictions
09:50 – 10:10 Szabolcs Bodizs, Uppsala University
Asymmetric hybrid state formation during phytochrome dark reversion reveals atom-scale control of the biliverdin dark reversion kinetics
10:10 – 10:30 Ajda Krc, Stockholm University
Structure and dynamics of the Complete 14-subunit Botulinum Neurotoxin B Complex
10:30 – 10:50 Coffee
10:50 – 11:10 Ane Metola, Stockholm University
Co-translational folding of a multidomain protein: de novo folding occurs through stabilization of an intermediate while global folding is delayed
11:10 – 11:30 Gabriel Ducrocq, Linköping University
CRYOSPHERE: Single-particle heterogeneous reconstruction from cryo-EM
11:30 – 11:50 Closing of meeting and award of prizes for best presentation and poster
12:00 – 13:00 Lunch + Departure
SCIENTIFIC COMMITTEE
The organizing committee for the 2025 meeting is composed of:
- Prof. Pål Stenmark
- Prof. Martin Högbom
- Dr. Martin Moche
- Dr. Marta Carroni
- Prof. Luca Jovine
- Prof. David Drew
- Prof. Arne Elofsson
- Prof. Astrid Gräslund